Thank you. One of the reasons I write some of these posts on the edgier side is to make the issues visible. The moment you challenge the status quo, the conversation shifts and substance such as the balance of cost and benefit gets lost in pile-ons and personal attacks. We have the most expensive healthcare system in the world, and we’ve spent hundreds of billions of dollars across both private and federal contexts pursuing oncogenes as the central therapeutic strategy against cancer. It has produced interesting basic science but very small gains in outcomes. This has been going on for over 30 years. The reduction in cancer mortality from this approach has been very limited. Compared to interventions like reducing smoking or obesity, it’s a drop in the bucket.